The 340B program is a powerful tool for covered entities, providing much-needed financial relief to support underserved communities. But while many organizations participate in the program, not all maximize its full potential.

Through our work with healthcare organizations, we’ve seen firsthand what sets the most successful 340B programs apart. These high-performing programs share key practices that keep them compliant, efficient, and financially optimized—ensuring they can continue to provide critical care without unnecessary risk.

So, what do these top-tier programs have in common? Let’s break it down.

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 They Stay Audit-Ready Year-Round

Waiting for an HRSA audit to prepare documentation? That’s a recipe for stress. The best 340B programs don’t scramble at the last minute—they stay prepared every day.

✅ Up-to-date policies and procedures that reflect current regulations
✅ Regular internal audits to catch and fix issues before an external review
✅ Detailed eligibility documentation that’s always ready for review

By maintaining compliance on an ongoing basis, these organizations avoid surprises and ensure they can defend their program integrity at any time.

They Optimize Their TPA Software

A third-party administrator (TPA) is essential for managing 340B operations, but even the best software isn’t perfect. Leading programs go beyond simply relying on their TPA—they actively manage and fine-tune their system for efficiency.

💡 What they do differently:

• Conduct regular audits to catch inaccuracies early
• Adjust software configurations to prevent split-billing and replenishment errors
• Monitor transaction logs to ensure every eligible prescription is properly captured

Instead of letting the software dictate their processes, they refine their systems to work for them, leading to better financial outcomes and fewer headaches.

They Continuously Monitor Savings & Capture Missed Opportunities

A common mistake? Leaving savings on the table. Successful 340B programs take a proactive approach to financial optimization without compromising compliance.

🚀 How they maximize savings:

• Regularly reviewing contract pharmacy performance to ensure strong partnerships
• Identifying missed replenishment opportunities and ensuring all eligible prescriptions are accounted for
• Tracking financial performance and adjusting strategies to increase 340B savings

By keeping a pulse on financial performance, these organizations make sure they’re leveraging every available opportunity while maintaining full compliance.

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Final Thoughts: Strengthen Your 340B Program Today

Every covered entity faces unique challenges, but the most successful 340B programs follow these best practices to stay ahead. Proactive compliance, strategic software management, and financial oversight aren’t just nice-to-haves—they’re essential for long-term success.

At RxTrail, we work alongside organizations like yours to help implement these strategies and ensure your 340B program is running at its full potential.

If you’d like to learn more about optimizing your program, reach out to us—we’re here to help.